Drug interactions
Sugammadex + Toremifene
Severity: Moderate
Sugammadex and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can bind sugammadex with notable affinity, so it may displace the neuromuscular blocker from sugammadex and delay reversal of blockade. The effect matters mainly when toremifene is taken on the day of surgery.
What this interaction means in plain words
Sugammadex and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sugammadex belongs to Miscellaneous; Toremifene belongs to Endocrine.
Why it happens
Toremifene competes with rocuronium or vecuronium for encapsulation by sugammadex, reducing the fraction of blocker bound.
What to do
Monitor neuromuscular function with quantitative train-of-four until full recovery. Be prepared for delayed recovery and continued ventilatory support if toremifene was taken recently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sugammadex
- Desogestrel-ethinyl estradiol + Sugammadex Moderate
- Ethinyl estradiol-drospirenone + Sugammadex Moderate
- Ethinyl estradiol-levonorgestrel + Sugammadex Moderate
- Etonogestrel + Sugammadex Moderate
- Levonorgestrel + Sugammadex Moderate
- Medroxyprogesterone + Sugammadex Moderate
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Sugammadex with Toremifene?
MediHelp rates the interaction as moderate. Sugammadex and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can bind sugammadex with notable affinity, so it may displace the neuromuscular blocker from sugammadex and delay reversal of blockade. The effect matters mainly when toremifene is taken on the day of surgery.
How serious is the interaction between Sugammadex and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with quantitative train-of-four until full recovery. Be prepared for delayed recovery and continued ventilatory support if toremifene was taken recently.
What other medicines interact with Sugammadex?
MediHelp also lists interactions of Sugammadex with, for example, Desogestrel-ethinyl estradiol, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Sugammadex page.
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