Drug interactions
Tacrolimus + Teclistamab
Severity: Moderate
Tacrolimus and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab induces cytokine release that can transiently suppress CYP450 activity, potentially increasing tacrolimus exposure. The risk is greatest during step-up dosing and cytokine release syndrome.
What this interaction means in plain words
Tacrolimus and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated down-regulation of CYP3A4 reduces tacrolimus clearance.
What to do
Monitor tacrolimus troughs and renal function around initiation and during cytokine release syndrome, adjusting the dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Tacrolimus with Teclistamab?
MediHelp rates the interaction as moderate. Tacrolimus and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab induces cytokine release that can transiently suppress CYP450 activity, potentially increasing tacrolimus exposure. The risk is greatest during step-up dosing and cytokine release syndrome.
How serious is the interaction between Tacrolimus and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus troughs and renal function around initiation and during cytokine release syndrome, adjusting the dose as required.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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