Drug interactions
Tasimelteon + Voriconazole
Severity: Minor
Tasimelteon and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is metabolized by CYP1A2 and CYP3A4, so voriconazole may increase its exposure. This could lead to more somnolence or other adverse effects, though the clinical impact is likely modest.
What this interaction means in plain words
Tasimelteon and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tasimelteon belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of tasimelteon.
What to do
No dose change is routinely required; monitor for excess drowsiness or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Tasimelteon with Voriconazole?
MediHelp rates the interaction as minor. Tasimelteon and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is metabolized by CYP1A2 and CYP3A4, so voriconazole may increase its exposure. This could lead to more somnolence or other adverse effects, though the clinical impact is likely modest.
How serious is the interaction between Tasimelteon and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor for excess drowsiness or headache.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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