Drug interactions
Tedizolid + Tramadol
Severity: Moderate
Tedizolid and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and may raise serotonin toxicity risk with tramadol. Clinical studies of tedizolid showed little serotonergic effect, so the real-world risk appears lower than with linezolid.
What this interaction means in plain words
Tedizolid and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tedizolid belongs to Anti Bacterial; Tramadol belongs to Musculoskeletal.
Why it happens
Weak reversible MAO inhibition by tedizolid may add to tramadol's serotonergic activity.
What to do
Monitor for signs of serotonin syndrome such as agitation, tremor, clonus and hyperthermia. Consider a non-serotonergic analgesic if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Tedizolid with Tramadol?
MediHelp rates the interaction as moderate. Tedizolid and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor and may raise serotonin toxicity risk with tramadol. Clinical studies of tedizolid showed little serotonergic effect, so the real-world risk appears lower than with linezolid.
How serious is the interaction between Tedizolid and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome such as agitation, tremor, clonus and hyperthermia. Consider a non-serotonergic analgesic if risk factors are present.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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