Drug interactions
Tedizolid + Trazodone
Severity: Major
Tedizolid and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity through reuptake inhibition and receptor effects, while tedizolid weakly inhibits MAO. Serotonin syndrome is possible in theory. Clinical evidence with tedizolid is limited.
What this interaction means in plain words
Tedizolid and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tedizolid belongs to Anti Bacterial; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from trazodone and weak MAO inhibition by tedizolid.
What to do
Prefer a non-serotonergic antibiotic. If co-use is needed, monitor for serotonin syndrome and consider holding trazodone during a short tedizolid course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tedizolid and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Tedizolid with Trazodone?
MediHelp rates the interaction as major. Tedizolid and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trazodone has serotonergic activity through reuptake inhibition and receptor effects, while tedizolid weakly inhibits MAO. Serotonin syndrome is possible in theory. Clinical evidence with tedizolid is limited.
How serious is the interaction between Tedizolid and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antibiotic. If co-use is needed, monitor for serotonin syndrome and consider holding trazodone during a short tedizolid course.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
