Drug interactions
Tedizolid + Vortioxetine
Severity: Major
Tedizolid and Vortioxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is a serotonin reuptake inhibitor and receptor modulator, and tedizolid weakly inhibits MAO. Serotonin syndrome is a theoretical concern with the pair. Clinical data are limited.
What this interaction means in plain words
Tedizolid and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tedizolid belongs to Anti Bacterial; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from vortioxetine and weak MAO inhibition by tedizolid.
What to do
Use an alternative antibiotic where possible. If combined, monitor for serotonin toxicity and stop one drug if it occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Tedizolid with Vortioxetine?
MediHelp rates the interaction as major. Tedizolid and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vortioxetine is a serotonin reuptake inhibitor and receptor modulator, and tedizolid weakly inhibits MAO. Serotonin syndrome is a theoretical concern with the pair. Clinical data are limited.
How serious is the interaction between Tedizolid and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If combined, monitor for serotonin toxicity and stop one drug if it occurs.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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