Drug interactions
Tenofovir alafenamide + Voclosporin
Severity: Moderate
Tenofovir alafenamide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause dose-related kidney toxicity, and tenofovir alafenamide can also affect renal tubules, although less than tenofovir disoproxil. Together they may increase the risk of declining renal function.
What this interaction means in plain words
Tenofovir alafenamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tenofovir alafenamide belongs to Anti Virals; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin-inhibitor renal vasoconstriction and tenofovir tubular effects.
What to do
Monitor eGFR, serum creatinine and phosphate regularly, and reduce or interrupt voclosporin per labeling if renal function falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Tenofovir alafenamide with Voclosporin?
MediHelp rates the interaction as moderate. Tenofovir alafenamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can cause dose-related kidney toxicity, and tenofovir alafenamide can also affect renal tubules, although less than tenofovir disoproxil. Together they may increase the risk of declining renal function.
How serious is the interaction between Tenofovir alafenamide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, serum creatinine and phosphate regularly, and reduce or interrupt voclosporin per labeling if renal function falls.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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