Drug interactions
Tepotinib + Testosterone
Severity: Minor
Tepotinib and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits intestinal and possibly systemic P-glycoprotein, and testosterone is a P-gp substrate. Exposure to testosterone could therefore rise, but the clinical consequence is poorly characterised and likely modest.
What this interaction means in plain words
Tepotinib and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tepotinib belongs to Oncology; Testosterone belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux transport by tepotinib may raise testosterone absorption and exposure.
What to do
No dose change is normally needed; monitor for androgenic adverse effects such as erythrocytosis or fluid retention and check serum testosterone if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tepotinib and Testosterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Testosterone?
MediHelp rates the interaction as minor. Tepotinib and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits intestinal and possibly systemic P-glycoprotein, and testosterone is a P-gp substrate. Exposure to testosterone could therefore rise, but the clinical consequence is poorly characterised and likely modest.
How serious is the interaction between Tepotinib and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for androgenic adverse effects such as erythrocytosis or fluid retention and check serum testosterone if symptoms occur.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
