Drug interactions
Teriflunomide + Tizanidine
Severity: Minor
Teriflunomide and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak inducer of CYP1A2 and may modestly reduce plasma levels of CYP1A2 substrates such as tizanidine. This could lessen the antispasticity effect of tizanidine.
What this interaction means in plain words
Teriflunomide and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Teriflunomide belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Weak induction of CYP1A2 by teriflunomide increases tizanidine metabolism.
What to do
Monitor spasticity control after teriflunomide is started and increase tizanidine dose if the response is inadequate. Reassess dosing if teriflunomide is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Teriflunomide with Tizanidine?
MediHelp rates the interaction as minor. Teriflunomide and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak inducer of CYP1A2 and may modestly reduce plasma levels of CYP1A2 substrates such as tizanidine. This could lessen the antispasticity effect of tizanidine.
How serious is the interaction between Teriflunomide and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spasticity control after teriflunomide is started and increase tizanidine dose if the response is inadequate. Reassess dosing if teriflunomide is stopped.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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