Drug interactions
Ticlopidine + Voriconazole
Severity: Moderate
Ticlopidine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, an important pathway for voriconazole clearance, and may raise voriconazole levels. This could increase visual, hepatic and QT-related adverse effects.
What this interaction means in plain words
Ticlopidine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticlopidine belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C19 (and possibly CYP2C9) by ticlopidine reduces voriconazole metabolism.
What to do
Monitor voriconazole trough levels, liver tests and visual or neurologic symptoms. Consider a different antiplatelet agent if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ticlopidine
Frequently asked questions
Can I take Ticlopidine with Voriconazole?
MediHelp rates the interaction as moderate. Ticlopidine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, an important pathway for voriconazole clearance, and may raise voriconazole levels. This could increase visual, hepatic and QT-related adverse effects.
How serious is the interaction between Ticlopidine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough levels, liver tests and visual or neurologic symptoms. Consider a different antiplatelet agent if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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