Drug interactions
Tiotropium-olodaterol + Trazodone
Severity: Minor
Tiotropium-olodaterol and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has weak anticholinergic activity and may slightly add to the antimuscarinic effects of tiotropium. Trazodone can also prolong the QT interval, which is relevant with a beta2 agonist.
What this interaction means in plain words
Tiotropium-olodaterol and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tiotropium-olodaterol belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Weak additive antimuscarinic effects and possible additive cardiac effects.
What to do
No routine action; monitor for dry mouth, urinary retention and palpitations in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium-olodaterol
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Tiotropium-olodaterol with Trazodone?
MediHelp rates the interaction as minor. Tiotropium-olodaterol and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has weak anticholinergic activity and may slightly add to the antimuscarinic effects of tiotropium. Trazodone can also prolong the QT interval, which is relevant with a beta2 agonist.
How serious is the interaction between Tiotropium-olodaterol and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor for dry mouth, urinary retention and palpitations in at-risk patients.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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