Drug interactions
Tiotropium-olodaterol + Valbenazine
Severity: Moderate
Tiotropium-olodaterol and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and beta2-agonists such as olodaterol can contribute to QT prolongation and hypokalemia. Together they may modestly raise the risk of ventricular arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Tiotropium-olodaterol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium-olodaterol belongs to Respiratory; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization (QT prolongation), with beta2-agonist-related hypokalemia as a possible contributor.
What to do
Check an ECG and serum potassium and magnesium if there are risk factors such as congenital long QT, bradycardia, electrolyte disturbance or other QT-prolonging drugs. Correct electrolytes and reassess if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Tiotropium-olodaterol with Valbenazine?
MediHelp rates the interaction as moderate. Tiotropium-olodaterol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and beta2-agonists such as olodaterol can contribute to QT prolongation and hypokalemia. Together they may modestly raise the risk of ventricular arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Tiotropium-olodaterol and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and serum potassium and magnesium if there are risk factors such as congenital long QT, bradycardia, electrolyte disturbance or other QT-prolonging drugs. Correct electrolytes and reassess if palpitations or syncope occur.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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