Drug interactions
Tipranavir + Vilazodone
Severity: Moderate
Tipranavir and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir inhibits CYP3A4 and may raise vilazodone exposure, although tipranavir also induces enzymes, so the net effect is uncertain.
What this interaction means in plain words
Tipranavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by ritonavir-boosted tipranavir reduces vilazodone clearance.
What to do
Monitor for vilazodone adverse effects and reduce the dose to 20 mg daily if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Vilazodone?
MediHelp rates the interaction as moderate. Tipranavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir inhibits CYP3A4 and may raise vilazodone exposure, although tipranavir also induces enzymes, so the net effect is uncertain.
How serious is the interaction between Tipranavir and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone adverse effects and reduce the dose to 20 mg daily if poorly tolerated.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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