Drug interactions
Trazodone + Triclabendazole
Severity: Moderate
Trazodone and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and trazodone also carries a QT risk. Together they may increase the chance of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Trazodone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the QTc, or hold trazodone during the short triclabendazole course if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Trazodone with Triclabendazole?
MediHelp rates the interaction as moderate. Trazodone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval, and trazodone also carries a QT risk. Together they may increase the chance of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Trazodone and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor the QTc, or hold trazodone during the short triclabendazole course if risk is high.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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