Drug interactions
Trazodone + Trimipramine
Severity: Major
Trazodone and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination increases the risk of serotonin syndrome and may add to QT prolongation and orthostatic hypotension. Sedation is also additive.
What this interaction means in plain words
Trazodone and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Trazodone belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic, QT-prolonging and alpha-adrenergic blocking effects.
What to do
Avoid if possible; if combined, use low doses, monitor for serotonin toxicity, hypotension and sedation, and check an ECG when cardiac risk factors exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Trimipramine?
MediHelp rates the interaction as major. Trazodone and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination increases the risk of serotonin syndrome and may add to QT prolongation and orthostatic hypotension. Sedation is also additive.
How serious is the interaction between Trazodone and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, use low doses, monitor for serotonin toxicity, hypotension and sedation, and check an ECG when cardiac risk factors exist.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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