Drug interactions
Triclabendazole + Trimipramine
Severity: Minor
Triclabendazole and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole may inhibit CYP2C19, which contributes to trimipramine metabolism, possibly increasing trimipramine exposure. Tricyclic adverse effects could be amplified, though the course of triclabendazole is short.
What this interaction means in plain words
Triclabendazole and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Triclabendazole belongs to Anti Parasitic; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated trimipramine metabolism.
What to do
Monitor for anticholinergic, sedative and cardiac adverse effects during treatment. Adjust the trimipramine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Triclabendazole with Trimipramine?
MediHelp rates the interaction as minor. Triclabendazole and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole may inhibit CYP2C19, which contributes to trimipramine metabolism, possibly increasing trimipramine exposure. Tricyclic adverse effects could be amplified, though the course of triclabendazole is short.
How serious is the interaction between Triclabendazole and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic, sedative and cardiac adverse effects during treatment. Adjust the trimipramine dose if toxicity appears.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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