Drug interactions
Tucatinib + Voriconazole
Severity: Moderate
Tucatinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise voriconazole concentrations, increasing visual, hepatic, and QT effects. Voriconazole is not expected to meaningfully raise tucatinib, although tucatinib is itself a CYP3A4 substrate.
What this interaction means in plain words
Tucatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tucatinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Tucatinib inhibits CYP3A4, reducing voriconazole clearance.
What to do
Monitor for voriconazole toxicity, including liver function and QTc, and consider checking voriconazole trough levels. Reduce the voriconazole dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Voriconazole?
MediHelp rates the interaction as moderate. Tucatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise voriconazole concentrations, increasing visual, hepatic, and QT effects. Voriconazole is not expected to meaningfully raise tucatinib, although tucatinib is itself a CYP3A4 substrate.
How serious is the interaction between Tucatinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for voriconazole toxicity, including liver function and QTc, and consider checking voriconazole trough levels. Reduce the voriconazole dose if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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