Drug interactions
Vilazodone + Voriconazole
Severity: Moderate
Vilazodone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is metabolized primarily by CYP3A4, and strong inhibitors such as voriconazole raise its plasma levels. This increases the risk of serotonin toxicity, nausea, diarrhea and other dose-related adverse effects.
What this interaction means in plain words
Vilazodone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vilazodone belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, decreasing vilazodone clearance.
What to do
Reduce the vilazodone dose to a maximum of 20 mg daily during voriconazole use, and return to the prior dose after the inhibitor is stopped. Monitor for serotonergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Vilazodone with Voriconazole?
MediHelp rates the interaction as moderate. Vilazodone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is metabolized primarily by CYP3A4, and strong inhibitors such as voriconazole raise its plasma levels. This increases the risk of serotonin toxicity, nausea, diarrhea and other dose-related adverse effects.
How serious is the interaction between Vilazodone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vilazodone dose to a maximum of 20 mg daily during voriconazole use, and return to the prior dose after the inhibitor is stopped. Monitor for serotonergic symptoms.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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