Drug interactions
Vilazodone + Zolmitriptan
Severity: Moderate
Vilazodone and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase serotonergic activity, so using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. The risk is highest when starting or increasing doses.
What this interaction means in plain words
Vilazodone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vilazodone belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects of an SSRI/5-HT1A partial agonist and a 5-HT1B/1D agonist.
What to do
If both are needed, educate the patient on serotonin syndrome symptoms and monitor closely after dose changes. Stop both drugs and provide supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Vilazodone and Zolmitriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Vilazodone with Zolmitriptan?
MediHelp rates the interaction as moderate. Vilazodone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase serotonergic activity, so using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. The risk is highest when starting or increasing doses.
How serious is the interaction between Vilazodone and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, educate the patient on serotonin syndrome symptoms and monitor closely after dose changes. Stop both drugs and provide supportive care if symptoms appear.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
