相互作用
Clotrimazole + Eliglustat
重症度: 中等度
Clotrimazole and Eliglustat: moderate interaction.
最終更新日
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概要
Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
この相互作用をわかりやすく説明すると
Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Eliglustat belongs to Miscellaneous.
なぜ起こるのか
Clotrimazole inhibits CYP3A4, which contributes to eliglustat metabolism, particularly when CYP2D6 is limited.
対処法
Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClotrimazoleとEliglustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Clotrimazole with Eliglustat?
MediHelp rates the interaction as moderate. Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
How serious is the interaction between Clotrimazole and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
