藥物交互作用
Clarithromycin + Darolutamide
嚴重程度: 中度
Clarithromycin and Darolutamide: moderate interaction.
最後更新
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摘要
Clarithromycin may raise darolutamide exposure, increasing risk of adverse effects such as fatigue and, rarely, cardiac events. The effect is expected from combined P-gp and CYP3A4 inhibition.
用白話說明這項交互作用的意義
Clarithromycin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Darolutamide belongs to Miscellaneous.
為什麼會發生
Inhibition of P-gp and CYP3A4 reduces darolutamide efflux and metabolism.
處置方式
Monitor for darolutamide toxicity and reduce the dose if adverse reactions occur; consider a non-interacting antibiotic.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clarithromycin 的其他交互作用
Darolutamide 的其他交互作用
常見問題
Can I take Clarithromycin with Darolutamide?
MediHelp rates the interaction as moderate. Clarithromycin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise darolutamide exposure, increasing risk of adverse effects such as fatigue and, rarely, cardiac events. The effect is expected from combined P-gp and CYP3A4 inhibition.
How serious is the interaction between Clarithromycin and Darolutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide toxicity and reduce the dose if adverse reactions occur; consider a non-interacting antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
