藥物交互作用
Aceclofenac + Balsalazide
嚴重程度: 中度
Aceclofenac and Balsalazide: moderate interaction.
最後更新
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摘要
Balsalazide releases mesalamine in the colon, and aceclofenac is an NSAID. Both can affect the kidney, so combined use may add to the risk of renal impairment, particularly in dehydrated patients or those with existing kidney disease. Mesalamine itself rarely causes nephrotoxicity, but it is recognized.
用白話說明這項交互作用的意義
Aceclofenac and Balsalazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Balsalazide belongs to Gastrointestinal Tract.
為什麼會發生
Additive nephrotoxic potential through NSAID-mediated reduction of renal prostaglandins together with rare mesalamine-associated interstitial nephritis.
處置方式
Monitor serum creatinine and urine output periodically, especially at the start of therapy and in patients with renal risk factors. Prefer to avoid regular NSAID use in inflammatory bowel disease where possible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Balsalazide 的其他交互作用
Aceclofenac 的其他交互作用
常見問題
Can I take Aceclofenac with Balsalazide?
MediHelp rates the interaction as moderate. Aceclofenac and Balsalazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Balsalazide releases mesalamine in the colon, and aceclofenac is an NSAID. Both can affect the kidney, so combined use may add to the risk of renal impairment, particularly in dehydrated patients or those with existing kidney disease. Mesalamine itself rarely causes nephrotoxicity, but it is recognized.
How serious is the interaction between Aceclofenac and Balsalazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output periodically, especially at the start of therapy and in patients with renal risk factors. Prefer to avoid regular NSAID use in inflammatory bowel disease where possible.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Celecoxib. The full list is on the Balsalazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
