藥物交互作用
Amlodipine-perindopril + Calcium gluconate
嚴重程度: 中度
Amlodipine-perindopril and Calcium gluconate: moderate interaction.
最後更新
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摘要
Intravenous calcium gluconate can counteract calcium channel blocker effects and is used to treat overdose. In patients on amlodipine it may reduce the blood pressure lowering effect, but oral use rarely matters.
用白話說明這項交互作用的意義
Amlodipine-perindopril and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic antagonism, because increased extracellular calcium overcomes L-type channel blockade.
處置方式
Monitor blood pressure and heart rate during parenteral calcium administration. For oral supplements, monitor serum calcium only.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-perindopril 的其他交互作用
Calcium gluconate 的其他交互作用
常見問題
Can I take Amlodipine-perindopril with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can counteract calcium channel blocker effects and is used to treat overdose. In patients on amlodipine it may reduce the blood pressure lowering effect, but oral use rarely matters.
How serious is the interaction between Amlodipine-perindopril and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during parenteral calcium administration. For oral supplements, monitor serum calcium only.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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