藥物交互作用
Avatrombopag + Ketoconazole
嚴重程度: 中度
Avatrombopag and Ketoconazole: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ketoconazole inhibits CYP3A4 and can increase avatrombopag exposure. Excess effect may raise platelet counts and thrombotic risk.
用白話說明這項交互作用的意義
Avatrombopag and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
為什麼會發生
Inhibition of CYP3A4 (and CYP2C9 contribution) reduces avatrombopag clearance.
處置方式
Use the reduced starting dose recommended in labeling for dual CYP2C9/3A4 inhibitors and monitor platelet counts.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ketoconazole 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Avatrombopag with Ketoconazole?
MediHelp rates the interaction as moderate. Avatrombopag and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits CYP3A4 and can increase avatrombopag exposure. Excess effect may raise platelet counts and thrombotic risk.
How serious is the interaction between Avatrombopag and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced starting dose recommended in labeling for dual CYP2C9/3A4 inhibitors and monitor platelet counts.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
