藥物交互作用
Aprepitant + Guanfacine
嚴重程度: 中度
Aprepitant and Guanfacine: moderate interaction.
最後更新
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摘要
Aprepitant may increase guanfacine concentrations by inhibiting CYP3A4. This may cause hypotension, bradycardia and sedation.
用白話說明這項交互作用的意義
Aprepitant and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Guanfacine belongs to Cardiovascular.
為什麼會發生
Inhibition of CYP3A4-mediated guanfacine metabolism by aprepitant.
處置方式
Consider halving the extended-release guanfacine dose during coadministration. Monitor blood pressure, heart rate and sedation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Aprepitant 的其他交互作用
Guanfacine 的其他交互作用
常見問題
Can I take Aprepitant with Guanfacine?
MediHelp rates the interaction as moderate. Aprepitant and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may increase guanfacine concentrations by inhibiting CYP3A4. This may cause hypotension, bradycardia and sedation.
How serious is the interaction between Aprepitant and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the extended-release guanfacine dose during coadministration. Monitor blood pressure, heart rate and sedation.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
