藥物交互作用
Axicabtagene ciloleucel + Tofacitinib
嚴重程度: 嚴重
Axicabtagene ciloleucel and Tofacitinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
為什麼會發生
JAK inhibition suppresses T-cell signalling and may reduce CAR-T activity, with additive immunosuppression.
處置方式
Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tofacitinib 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Tofacitinib?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
How serious is the interaction between Axicabtagene ciloleucel and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
