藥物交互作用
Bismuth subsalicylate + Omadacycline
嚴重程度: 中度
Bismuth subsalicylate and Omadacycline: moderate interaction.
最後更新
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摘要
Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
用白話說明這項交互作用的意義
Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
為什麼會發生
Chelation of omadacycline by polyvalent bismuth cations in the GI tract reduces absorption.
處置方式
Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bismuth subsalicylate 的其他交互作用
Omadacycline 的其他交互作用
常見問題
Can I take Bismuth subsalicylate with Omadacycline?
MediHelp rates the interaction as moderate. Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
How serious is the interaction between Bismuth subsalicylate and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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