藥物交互作用
Calcium Carbonate + Cholecalciferol
嚴重程度: 中度
Calcium Carbonate and Cholecalciferol: moderate interaction.
最後更新
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摘要
Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
用白話說明這項交互作用的意義
Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium Carbonate belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.
為什麼會發生
Pharmacodynamic: cholecalciferol, via calcitriol, enhances active intestinal calcium absorption, adding to the calcium supplied by calcium carbonate.
處置方式
Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Calcium carbonate and cholecalciferol chewable tablets SmPC - Special Warnings and Interactions — EMA SmPC
Calcium Carbonate 的其他交互作用
Cholecalciferol 的其他交互作用
常見問題
Can I take Calcium Carbonate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
How serious is the interaction between Calcium Carbonate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
What other medicines interact with Calcium Carbonate?
MediHelp also lists interactions of Calcium Carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium Carbonate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
