藥物交互作用
Caplacizumab + Dabigatran etexilate
嚴重程度: 嚴重
Caplacizumab and Dabigatran etexilate: major interaction.
最後更新
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摘要
Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis, and dabigatran adds anticoagulant effect. Together they increase the risk of serious bleeding.
用白話說明這項交互作用的意義
Caplacizumab and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Dabigatran etexilate belongs to Cardiovascular.
為什麼會發生
Additive hemostatic impairment: antiplatelet-like vWF inhibition plus direct thrombin inhibition.
處置方式
Avoid concurrent use where possible; if anticoagulation is essential, monitor closely for bleeding and consider holding dabigatran during caplacizumab treatment. Withhold both before invasive procedures per labeling.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dabigatran etexilate 的其他交互作用
Caplacizumab 的其他交互作用
常見問題
Can I take Caplacizumab with Dabigatran etexilate?
MediHelp rates the interaction as major. Caplacizumab and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis, and dabigatran adds anticoagulant effect. Together they increase the risk of serious bleeding.
How serious is the interaction between Caplacizumab and Dabigatran etexilate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if anticoagulation is essential, monitor closely for bleeding and consider holding dabigatran during caplacizumab treatment. Withhold both before invasive procedures per labeling.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
