藥物交互作用
Cefotaxime + Streptomycin
嚴重程度: 中度
Cefotaxime and Streptomycin: moderate interaction.
最後更新
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摘要
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
用白話說明這項交互作用的意義
Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
為什麼會發生
Possible additive nephrotoxicity, with aminoglycoside-related renal tubular injury potentially worsening renal clearance and thus ototoxic exposure.
處置方式
Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefotaxime 的其他交互作用
Streptomycin 的其他交互作用
常見問題
Can I take Cefotaxime with Streptomycin?
MediHelp rates the interaction as moderate. Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
How serious is the interaction between Cefotaxime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
