藥物交互作用
Chloramphenicol + Olaparib
嚴重程度: 嚴重
Chloramphenicol and Olaparib: major interaction.
最後更新
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摘要
Olaparib is metabolized by CYP3A4, and inhibitors raise its exposure. This may increase myelosuppression such as anemia and neutropenia.
用白話說明這項交互作用的意義
Chloramphenicol and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Olaparib belongs to Oncology.
為什麼會發生
Chloramphenicol inhibits CYP3A4, reducing olaparib clearance.
處置方式
Avoid if possible. If unavoidable, reduce the olaparib dose per labeling for strong CYP3A inhibitors and monitor blood counts.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chloramphenicol 的其他交互作用
Olaparib 的其他交互作用
常見問題
Can I take Chloramphenicol with Olaparib?
MediHelp rates the interaction as major. Chloramphenicol and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib is metabolized by CYP3A4, and inhibitors raise its exposure. This may increase myelosuppression such as anemia and neutropenia.
How serious is the interaction between Chloramphenicol and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the olaparib dose per labeling for strong CYP3A inhibitors and monitor blood counts.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
