藥物交互作用
Chlorpromazine + Macimorelin
嚴重程度: 嚴重
Chlorpromazine and Macimorelin: major interaction.
最後更新
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摘要
Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.
用白話說明這項交互作用的意義
Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
為什麼會發生
Additive QT prolongation through effects on cardiac repolarization.
處置方式
Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpromazine 的其他交互作用
Macimorelin 的其他交互作用
常見問題
Can I take Chlorpromazine with Macimorelin?
MediHelp rates the interaction as major. Chlorpromazine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin produces a small QT prolongation, and chlorpromazine adds to this effect. The combination may increase the risk of torsade de pointes during the diagnostic test.
How serious is the interaction between Chlorpromazine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking chlorpromazine, or allow adequate washout of chlorpromazine before the test when it is safe to do so.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
