藥物交互作用
Cilastatin-imipenem + Probenecid
嚴重程度: 中度
Cilastatin-imipenem and Probenecid: moderate interaction.
最後更新
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摘要
Probenecid raises plasma concentrations and prolongs the half-life of imipenem and cilastatin. This may increase the risk of dose-related adverse effects such as seizures.
用白話說明這項交互作用的意義
Cilastatin-imipenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilastatin-imipenem belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
為什麼會發生
Probenecid inhibits renal tubular secretion of imipenem and cilastatin.
處置方式
Coadministration is generally not recommended as it offers no therapeutic benefit. If used, monitor for neurotoxicity and adjust imipenem dose for renal function.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cilastatin-imipenem 的其他交互作用
Probenecid 的其他交互作用
常見問題
Can I take Cilastatin-imipenem with Probenecid?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid raises plasma concentrations and prolongs the half-life of imipenem and cilastatin. This may increase the risk of dose-related adverse effects such as seizures.
How serious is the interaction between Cilastatin-imipenem and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is generally not recommended as it offers no therapeutic benefit. If used, monitor for neurotoxicity and adjust imipenem dose for renal function.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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