藥物交互作用
Crizotinib + Danicopan
嚴重程度: 中度
Crizotinib and Danicopan: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Danicopan inhibits P-glycoprotein and may increase crizotinib exposure. This may heighten crizotinib adverse effects including hepatotoxicity and QT prolongation.
用白話說明這項交互作用的意義
Crizotinib and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Danicopan belongs to Miscellaneous.
為什麼會發生
Danicopan inhibits P-gp efflux, increasing crizotinib bioavailability.
處置方式
Monitor for crizotinib toxicity, including liver tests and ECG. Consider a crizotinib dose reduction if adverse effects appear.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Crizotinib 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Crizotinib with Danicopan?
MediHelp rates the interaction as moderate. Crizotinib and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase crizotinib exposure. This may heighten crizotinib adverse effects including hepatotoxicity and QT prolongation.
How serious is the interaction between Crizotinib and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for crizotinib toxicity, including liver tests and ECG. Consider a crizotinib dose reduction if adverse effects appear.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
