藥物交互作用
Digoxin + Torsemide
嚴重程度: 嚴重
Digoxin and Torsemide: major interaction.
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
摘要
Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
用白話說明這項交互作用的意義
Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
為什麼會發生
Pharmacodynamic: diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its arrhythmogenic effects.
處置方式
Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Torsemide 的其他交互作用
Digoxin 的其他交互作用
常見問題
Can I take Digoxin with Torsemide?
MediHelp rates the interaction as major. Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
How serious is the interaction between Digoxin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
