藥物交互作用
Dipyridamole + Venetoclax
嚴重程度: 嚴重
Dipyridamole and Venetoclax: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.
用白話說明這項交互作用的意義
Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dipyridamole belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
為什麼會發生
Dipyridamole inhibits P-glycoprotein efflux of venetoclax, increasing its systemic exposure.
處置方式
Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dipyridamole 的其他交互作用
Venetoclax 的其他交互作用
常見問題
Can I take Dipyridamole with Venetoclax?
MediHelp rates the interaction as major. Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.
How serious is the interaction between Dipyridamole and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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