藥物交互作用
Doxycycline + Magnesium sulphate
嚴重程度: 中度
Doxycycline and Magnesium sulphate: moderate interaction.
最後更新
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摘要
Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
用白話說明這項交互作用的意義
Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
為什麼會發生
Chelation of doxycycline by divalent magnesium cations in the gastrointestinal tract, forming poorly absorbed complexes.
處置方式
Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium sulphate 的其他交互作用
Doxycycline 的其他交互作用
常見問題
Can I take Doxycycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
How serious is the interaction between Doxycycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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