藥物交互作用
Golimumab + Rozanolixizumab
嚴重程度: 中度
Golimumab and Rozanolixizumab: moderate interaction.
最後更新
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摘要
Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG molecules and prolongs their half-life. Golimumab is an IgG1 monoclonal antibody, so its clearance could increase and exposure and efficacy fall.
用白話說明這項交互作用的意義
Golimumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Golimumab belongs to Musculoskeletal; Rozanolixizumab belongs to Miscellaneous.
為什麼會發生
FcRn blockade by rozanolixizumab increases catabolism of IgG-based drugs such as golimumab.
處置方式
Monitor for loss of golimumab efficacy during and after rozanolixizumab cycles. If disease control worsens, consider alternative therapy or timing doses away from rozanolixizumab treatment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Golimumab 的其他交互作用
Rozanolixizumab 的其他交互作用
常見問題
Can I take Golimumab with Rozanolixizumab?
MediHelp rates the interaction as moderate. Golimumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG molecules and prolongs their half-life. Golimumab is an IgG1 monoclonal antibody, so its clearance could increase and exposure and efficacy fall.
How serious is the interaction between Golimumab and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of golimumab efficacy during and after rozanolixizumab cycles. If disease control worsens, consider alternative therapy or timing doses away from rozanolixizumab treatment.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
