藥物交互作用
Itraconazole + Rifaximin
嚴重程度: 中度
Itraconazole and Rifaximin: moderate interaction.
最後更新
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摘要
Itraconazole is a strong P-glycoprotein inhibitor and can raise systemic rifaximin exposure. The effect is generally modest but may be more relevant in severe liver disease.
用白話說明這項交互作用的意義
Itraconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Rifaximin belongs to Anti Bacterial.
為什麼會發生
P-glycoprotein inhibition by itraconazole reduces intestinal efflux of rifaximin.
處置方式
Use usual rifaximin doses and monitor for adverse effects; be especially watchful in patients with Child-Pugh C disease.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Rifaximin 的其他交互作用
Itraconazole 的其他交互作用
常見問題
Can I take Itraconazole with Rifaximin?
MediHelp rates the interaction as moderate. Itraconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong P-glycoprotein inhibitor and can raise systemic rifaximin exposure. The effect is generally modest but may be more relevant in severe liver disease.
How serious is the interaction between Itraconazole and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use usual rifaximin doses and monitor for adverse effects; be especially watchful in patients with Child-Pugh C disease.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
