藥物交互作用
Sapropterin + Sildenafil
嚴重程度: 輕微
Sapropterin and Sildenafil: minor interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Sapropterin can promote nitric oxide synthesis, and sildenafil enhances nitric oxide signalling, so additive vasodilation is theoretically possible. This could lower blood pressure, although clinically significant effects have not been well documented.
用白話說明這項交互作用的意義
Sapropterin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sapropterin belongs to Miscellaneous; Sildenafil belongs to Genitourinary.
為什麼會發生
Additive vasodilation through enhanced nitric oxide synthesis (sapropterin) and cGMP preservation (sildenafil).
處置方式
Monitor blood pressure and ask about dizziness when starting the combination; counsel patients to rise slowly.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Sildenafil 的其他交互作用
Sapropterin 的其他交互作用
常見問題
Can I take Sapropterin with Sildenafil?
MediHelp rates the interaction as minor. Sapropterin and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sapropterin can promote nitric oxide synthesis, and sildenafil enhances nitric oxide signalling, so additive vasodilation is theoretically possible. This could lower blood pressure, although clinically significant effects have not been well documented.
How serious is the interaction between Sapropterin and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ask about dizziness when starting the combination; counsel patients to rise slowly.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
