藥物交互作用
Sapropterin + Tadalafil
嚴重程度: 中度
Sapropterin and Tadalafil: moderate interaction.
最後更新
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摘要
Sapropterin is a cofactor for nitric oxide synthase and may increase nitric oxide production. Combined with a PDE5 inhibitor this could cause additive vasodilation and low blood pressure.
用白話說明這項交互作用的意義
Sapropterin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sapropterin belongs to Miscellaneous; Tadalafil belongs to Genitourinary.
為什麼會發生
Sapropterin may enhance nitric oxide synthesis while tadalafil prolongs cGMP signalling, a theoretical additive vasodilatory effect.
處置方式
Monitor blood pressure when the drugs are started together or doses changed. Counsel patients to report dizziness or fainting.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Tadalafil 的其他交互作用
Sapropterin 的其他交互作用
常見問題
Can I take Sapropterin with Tadalafil?
MediHelp rates the interaction as moderate. Sapropterin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for nitric oxide synthase and may increase nitric oxide production. Combined with a PDE5 inhibitor this could cause additive vasodilation and low blood pressure.
How serious is the interaction between Sapropterin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the drugs are started together or doses changed. Counsel patients to report dizziness or fainting.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
