Drug interactions
Levoketoconazole + Silodosin
Severity: Contraindicated
Levoketoconazole and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can markedly raise silodosin exposure. This may cause excessive alpha-1 blockade with orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Levoketoconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Silodosin belongs to Genitourinary.
Why it happens
Strong inhibition of CYP3A4 (and P-glycoprotein) reduces the metabolism and efflux of silodosin, increasing its plasma concentrations.
What to do
Do not co-administer; silodosin labeling contraindicates strong CYP3A4 inhibitors. Use an alternative treatment for either condition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Silodosin?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor and can markedly raise silodosin exposure. This may cause excessive alpha-1 blockade with orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Levoketoconazole and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; silodosin labeling contraindicates strong CYP3A4 inhibitors. Use an alternative treatment for either condition.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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