Drug interactions
Amisulpride + Apomorphine
Severity: Major
Amisulpride and Apomorphine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride blocks dopamine receptors and opposes the effect of apomorphine, a dopamine agonist, which can worsen Parkinson's disease symptoms. Both drugs can also prolong the QT interval, adding arrhythmia risk.
What this interaction means in plain words
Amisulpride and Apomorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Apomorphine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors, plus additive QT prolongation.
What to do
Avoid the combination. If an antipsychotic is needed in Parkinson's disease, choose one with minimal D2 blockade and monitor the ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Amisulpride with Apomorphine?
MediHelp rates the interaction as major. Amisulpride and Apomorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride blocks dopamine receptors and opposes the effect of apomorphine, a dopamine agonist, which can worsen Parkinson's disease symptoms. Both drugs can also prolong the QT interval, adding arrhythmia risk.
How serious is the interaction between Amisulpride and Apomorphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an antipsychotic is needed in Parkinson's disease, choose one with minimal D2 blockade and monitor the ECG and electrolytes.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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