Drug interactions
Amisulpride + Ozanimod
Severity: Moderate
Amisulpride and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and its labeling notes caution with QT-prolonging drugs. With amisulpride, bradycardia may increase the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation combined with S1P-receptor-mediated bradycardia that promotes arrhythmia.
What to do
Review baseline ECG and heart rate before starting ozanimod in a patient on amisulpride. Monitor heart rate and QTc, and avoid other bradycardic or QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Amisulpride with Ozanimod?
MediHelp rates the interaction as moderate. Amisulpride and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and its labeling notes caution with QT-prolonging drugs. With amisulpride, bradycardia may increase the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and heart rate before starting ozanimod in a patient on amisulpride. Monitor heart rate and QTc, and avoid other bradycardic or QT-prolonging drugs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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