Drug interactions
Amlodipine-atorvastatin + Avanafil
Severity: Moderate
Amlodipine-atorvastatin and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil, a PDE5 inhibitor, has vasodilating effects and can add to the blood pressure lowering of amlodipine. This may cause symptomatic hypotension, dizziness or syncope.
What this interaction means in plain words
Amlodipine-atorvastatin and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation from nitric oxide/cGMP enhancement and calcium channel blockade.
What to do
Use the lowest avanafil dose initially and counsel patients about hypotension symptoms; monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Avanafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil, a PDE5 inhibitor, has vasodilating effects and can add to the blood pressure lowering of amlodipine. This may cause symptomatic hypotension, dizziness or syncope.
How serious is the interaction between Amlodipine-atorvastatin and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest avanafil dose initially and counsel patients about hypotension symptoms; monitor blood pressure.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
