Drug interactions
Amlodipine-atorvastatin + Enzalutamide
Severity: Major
Amlodipine-atorvastatin and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower amlodipine and atorvastatin concentrations. This can lead to reduced blood pressure control and weaker lipid lowering. The induction persists for weeks after stopping enzalutamide.
What this interaction means in plain words
Amlodipine-atorvastatin and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, accelerating the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid levels, and titrate the doses upward if needed, or choose alternatives less affected by CYP3A4 induction. Reassess dosing after enzalutamide is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Enzalutamide?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and may lower amlodipine and atorvastatin concentrations. This can lead to reduced blood pressure control and weaker lipid lowering. The induction persists for weeks after stopping enzalutamide.
How serious is the interaction between Amlodipine-atorvastatin and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid levels, and titrate the doses upward if needed, or choose alternatives less affected by CYP3A4 induction. Reassess dosing after enzalutamide is stopped.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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