Drug interactions
Amlodipine-atorvastatin + Posaconazole
Severity: Major
Amlodipine-atorvastatin and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can raise amlodipine and atorvastatin exposure. This increases the risk of hypotension and edema, and of myopathy or rhabdomyolysis from atorvastatin.
What this interaction means in plain words
Amlodipine-atorvastatin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Strong inhibition of CYP3A4 by posaconazole reduces the metabolism of amlodipine and atorvastatin.
What to do
Temporarily withhold or limit the statin during posaconazole therapy, using separate agents to allow dose control. Monitor blood pressure and muscle symptoms, and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-atorvastatin
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Posaconazole?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor and can raise amlodipine and atorvastatin exposure. This increases the risk of hypotension and edema, and of myopathy or rhabdomyolysis from atorvastatin.
How serious is the interaction between Amlodipine-atorvastatin and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Temporarily withhold or limit the statin during posaconazole therapy, using separate agents to allow dose control. Monitor blood pressure and muscle symptoms, and check creatine kinase if symptoms occur.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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