Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Silodosin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, and combining it with the antihypertensive trio may increase dizziness and syncope. The uroselective profile lowers but does not remove this risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive blood pressure lowering from alpha-1 blockade with calcium channel blockade, angiotensin receptor blockade and diuresis.
What to do
Counsel patients to rise slowly and monitor orthostatic blood pressure after starting silodosin. Adjust antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Silodosin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, and combining it with the antihypertensive trio may increase dizziness and syncope. The uroselective profile lowers but does not remove this risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to rise slowly and monitor orthostatic blood pressure after starting silodosin. Adjust antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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