Drug interactions
Amlodipine-perindopril + Apalutamide
Severity: Moderate
Amlodipine-perindopril and Apalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a CYP3A4 inducer and can lower amlodipine concentrations, reducing blood pressure control. The effect develops over days to weeks as induction builds up.
What this interaction means in plain words
Amlodipine-perindopril and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Apalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 increases the hepatic and intestinal metabolism of amlodipine.
What to do
Monitor blood pressure after starting apalutamide and increase amlodipine dose if needed. Reassess dose again if apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Apalutamide?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a CYP3A4 inducer and can lower amlodipine concentrations, reducing blood pressure control. The effect develops over days to weeks as induction builds up.
How serious is the interaction between Amlodipine-perindopril and Apalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting apalutamide and increase amlodipine dose if needed. Reassess dose again if apalutamide is stopped.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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