Drug interactions
Amlodipine-perindopril + Aprepitant
Severity: Minor
Amlodipine-perindopril and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and may modestly increase amlodipine exposure, which could enhance hypotension or edema. The effect is usually small with short antiemetic courses.
What this interaction means in plain words
Amlodipine-perindopril and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, decreasing amlodipine clearance.
What to do
Monitor blood pressure and for dizziness or edema during aprepitant courses. Reduce the amlodipine dose only if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-perindopril with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor and may modestly increase amlodipine exposure, which could enhance hypotension or edema. The effect is usually small with short antiemetic courses.
How serious is the interaction between Amlodipine-perindopril and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for dizziness or edema during aprepitant courses. Reduce the amlodipine dose only if symptomatic.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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